I basically drew my own family. My father's name is Homer. My mother's name is Margaret. I have a sister Lisa and another sister Maggie, so I drew all of them. I was going to name the main character Matt, but I didn't think it would go over well in a pitch meeting, so I changed the name to Bart.

In 'Futurama,' the skin color is no longer yellow. They have actually evolved to cartoon skin tone. But they still have four fingers.

God often gives nuts to toothless people.

The amazing thing about Freak Out! was that there was nothing quite like it in rock 'n roll at the time. It was really simultaneously crude and ugly, and incredibly sophisticated. The Beatles were funny, but there was nothing with the kind of sneer that you could feel in the music of Frank Zappa.

The conundrum that I face on a daily basis is that I have two sons who have grown up watching 'The Simpsons,' so they know exactly what buttons to push. They know how Bart irritates Homer, and they use these lines against me to tell me that I'm not funny anymore.

The next time you are contemplating a decision in which you are debating whether or not to go for the gusto, ask yourself this important question: "How long am I going to be dead?" With that perspective, you can now make a free, fearless choice to do just about any goddamned sneaky thing your devious little mind can think up. Go ahead. Have your fun. You're welcome. Go on. See you in hell.

I went through a phase where people would introduce me at parties as a cartoonist, and everybody felt sorry for me. 'Oh, Matt's a cartoonist.' Then people further feeling sorry for me would ask me to draw Garfield. Because I'm a cartoonist, draw Snoopy or Garfield or something.