Here's to alcohol: the cause of, and answer to, all of life's problems.

'The Simpsons' is about alienation and the ambivalence of living with a family who you love but who drive you completely crazy.

I basically drew my own family. My father's name is Homer. My mother's name is Margaret. I have a sister Lisa and another sister Maggie, so I drew all of them. I was going to name the main character Matt, but I didn't think it would go over well in a pitch meeting, so I changed the name to Bart.

I know for a fact, obviously, because my kids grew up watching the show, that there are some things they are introduced to from 'The Simpsons', and then later in life they see the thing we're parodying. My kids had not seen 'Casablanca,' and we'd done parodies of 'Casablanca.'

Are we alone in an uncaring universe, or is God some kind of wiseguy?

The thing about a cartoon is, you can do whatever you want. The tightrope that we are walking on 'The Simpsons' and 'Futurama' is "How do you continue to surprise the audience, but make them good surprises?" Not every surprise is good, but you want to continue jolting people.

The conundrum that I face on a daily basis is that I have two sons who have grown up watching 'The Simpsons,' so they know exactly what buttons to push. They know how Bart irritates Homer, and they use these lines against me to tell me that I'm not funny anymore.