Do things that incumbents can't or won't do because it's economically or technically infeasible.
Modularize, don't customize. Build a platform as opposed to building all of the custom technology and custom vertical experiences.
Better to be too early and have to try again, than be too late and have to catch up.
The chance of failure is almost always better than the guarantee of never knowing.
In the enterprise you want to start intentionally small.
Sometimes things are the way they are and can't be changed, other times it's because no one ever tried. Your job is to find the latter.