Cultures, for better or worse, are very stable.
There'll always be serendipity involved in discovery.
The common question that gets asked in business is, why? That’s a good question, but an equally valid question is, why not?
Above all else, align with customers. Win when they win. Win only when they win.
If you invent frequently and are willing to fail, then you never get to that point where you really need to bet the whole company.
Read the Declaration of Independence to your children as a tradition every Fourth of July. Make sure they understand why the word "pursuit" precedes the word "happiness."