The real question is should we trust people who don't like cheese?

I always want my standup act to appeal to everybody in the room, and when I started standup, and I would see people talk about their kids and their wife, and I'd always cringe a little bit, like, 'I can't get a date, I don't know what you're talking about.'

As I go on in standup, I keep being described as cleaner and cleaner as I do each hour, they're like, 'It's unbelievable how clean,' 'He's the cleanest person in the world.' And then I'll do shows and people will be like, 'You're supposed to be so clean, but you're talking about cancer.'

I was still rooting for Notre Dame.It's like there's the cultural Catholic experience.

I think it's important to control your opportunities, because in the entertainment world, it's not up to you. I'm not sitting here under this naïve belief that someone in Hollywood is going, "Gaffigan! What kind of a show can I build around him?" So you have to find things that can showcase your point of view.

You ever read a book that changed your life? Me neither.

There are people that are vegetarians that love bacon.