Sometimes people try to read into my strip and find out what my state of mind is. And I can say if I'm in a good mood, generally the comic strip starts out in a good mood, but the punchline is very negative and sour.

When The Simpsons came around, there really was nothing else like it on TV. It's hard to imagine, but when Fox first took the plunge with it, it was considered controversial to put animation on prime time.

When I look at the smiles on all the children's faces...I just know they're about to jab me with something.

'The Simpsons' was about children and married parents; 'Futurama' is about people in between; they're growing up and haven't settled down. Every other cartoon show seemed to be, you know, dumb dad, bratty kids.

The entire world of grown-ups is corrupt and stupid.

Of course I’ve gone mad with power! Have you ever tried going mad without power? It’s boring and no one listens to you! — Russ Cargill

Are we alone in an uncaring universe, or is God some kind of wiseguy?