In general don't start a startup you're not willing to work on for ten years.
In addition to relentlessly resourceful, you want a tough and a calm cofounder.
Just put a little pin in your mind: when you cross 50 employees, there are a new set of HR rules that you have to comply with.
Keep salaries low and equity high. Keep the organization as flat as you can.
For most of the early hires you make in a startup, experience doesn't matter very much, and you should go for aptitude.
You don't get to make their decisions but you do get to choose the decision makers.