We've got some great big problems in our world. We have to figure out how to feed 10 billion people. Too many people can't access clean water, quality healthcare, and reasonable education. We have to figure out what to do about climate change, income inequality, and more. Innovators need to rise to the challenge!

I think it is only in hindsight that you can determine whether something is a mistake or not.

You still want to be thoughtful about what you do, no doubt, but you have to learn through trial-and-error experimentation as well.

What looks like resistance in many cases is rational responses to incentives and ingrained resource-allocation processes.

The reality is customers lie - not because they want to want to deceive you, but because they don't do a good job of predicting what they will do in the future.

History teaches us that many breakthroughs were happy accidents. Whether that's penicillin coming from Fleming neglecting to clean his laboratory before going on vacation or the team at Odeon trying a little side project that allowed people to communicate in real time as long as their message was 140 characters or less (which ultimately of course became Twitter), the unintended is often the transformational.

Make sure that you take the time to think about how other companies might respond to your idea, both those companies already in the market you plan to target as well as others that might imagine targeting that market.