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If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (-), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.
Charles Scott SherringtonI still believe that standing up for the truth of God is the greatest thing in the world. This is the end (purpose) of life. The end of life is not to be happy. The end of life is not to achieve pleasure and avoid pain. The end of life is to do the will of God, come what may.
Martin Luther King, Jr.I've been trying to fit everything in, trying to get to the end before it's too late, but I see now how badly I've deceived myself. Words do not allow such things. The closer you come to the end, the more there is to say. The end is only imaginary, a destination you invent to keep yourself going, but a point comes when you realize you will never get there. You might have to stop, but that is only because you have run out of time. You stop, but that does not mean you have come to an end.
Paul AusterA story is an end in itself. It is not written to teach, sell, explain or destroy anything. It is not written even to entertain. It is written as a man is born - an organic whole, dictated only by its own laws and its own necessity - an end in itself, not a means to an end.
Ayn RandNow this is not the end. It is not even the beginning of the end. But it is, perhaps, the end of the beginning.
Winston ChurchillAs the diagnosis of autism is increasing the diagnosis of mental retardation is decreasing. And more and more on the other end, the high end, more children who are just a little bit off, who ordinarily you would not single out now are being described as perhaps Aspergerโs syndrome or on the high end of the autism spectrum, so I donโt believe there is an epidemic.
Gerald FischbachThe first half was end-to-end stuff. In contrast, in this second half it's been one end to the other.
Lou MacariYou believe you can make it every year. You don't think it's going to end. But the reality is that most teams, you end up in, you end up out.
Lindy RuffIt's an end of the world I guess. I guess you'd currently call it disaster movie. But really they weren't disaster movies. They were more end of the world movies. This is more an end of the world movie.
Michael O'DonoghueExtraordinarily excessive sensuality it may be .. but it all comes down to the same thing in the end, and one means is surely as good as another, since the end obtained is always the same. In any case the exceptional, endlessly repeated, is no different than the banal; and unceasing recapitulation can add nothing, in the end, to the sum of experience. I am weary and hopeless three times the dupe. Why have you trained me in the shame of abominable sins?
Remy de Gourmont...There is no end to the making and selling of things there is no end to the making and selling of things there is no end... Man, it occurs to me, is a joyful, buying-and-selling piece of work. I have been wrong, dead wrong, when I've decried consumerism. Consumerism is what we are. It is, in a sense, a holy impulse. A human being is someone who joyfully goes in pursuit of things, brings them home, then immediately starts planning how to get more.
George SaundersI've seen the end of the universe, and it happens to be in the United States and, oddly enough, it's in Houston, Texas. I know - I was shocked, too. Imagine my surprise when I left a comedy club one day and walked to the end of the block, and there on one corner was a Starbucks, and across the street from that Starbucks, in the exact same building as that Starbucks, there was - a Starbucks. I looked back and forth, thinking the sun was playing tricks with my eyes. That there was a Starbucks across from a Starbucks - and that, my friends, is the end of the universe.
Lewis BlackWe are so anxious to achieve some particular end that we never pay attention to the psycho-physical means whereby that end is to be gained. So far as we are concerned, any old means is good enough. But the nature of the universe is such that ends can never justify the means. On the contrary, the means always determine the end.
Aldous HuxleyChristmas turns things tail-end foremost. The day and the spirit of Christmas rearrange the world parade. As the world arranges it, usually there come first in importance -- leading the parade with a big blare of a band -- the Big Shots. Frequently they are also the Stuffed Shirts. That's the first of the parade. Then at the tail end, as of little importance, trudge the weary, the poor, the lame, the halt, and the blind. But in the Christmas spirit, the procession is turned around. Those at the tail end are put first in the arrangement of the Child of Christmas.
Bill VaughanAcquisition of knowledge is not the end, but the means to the end; the end consists in the attainment, thanks to this knowledge of the higher worlds, of greater and truer self-confidence, a higher degree of courage, and a magnanimity and perseverance such as cannot, as a rule, be acquired in the lower world.
Rudolf SteinerIn stories, everything has to have clear consequences and everything has to focus to the end. Everything at the end will give meaning to everything that precedes. In my own life, the consequences of the choices I've made aren't always very clear. The most beautiful things are sometimes not totally truthful, and the end will not give more meaning to everything that precedes.
Jaco Van DormaelSince God is the end of man, since he has created us to be perfect and happy in him, it is manifest that if the designs of creation have not here below been entirely frustrated, there should be found men who tend to their end in seeking and loving God. And nevertheless, because of human liberty, there should also be found other men who neglect God, their principle and their end, and yield to the seduction of created things. Such indeed is the spectacle which the history of the world unceasingly presents to us.
Jean-Baptiste Henri LacordairePropaganda is not an end in itself, but a means to an end. If the means achieves the end then the means is good... the new Ministry has no other aim than to unite the nation behind the ideal of the national revolution.
Joseph GoebbelsThe world, as we know it, is coming to an end. The world as the center of the universe, the world divided from the heavens, the world bound by horizons in which love is reserved for members of the in-group: that is the world that is passing away. Apocalypse does not point to a fiery Armageddon but to the fact that our ignorance and complacency are coming to an end.
Joseph CampbellIf you spot a market where the only choices are at either one end or the other - high fidelity or high convenience - there's probably a big opportunity at the other end. That was the opening for Federal Express, for instance. When it started, there was only one mail service in America - the US Postal Service, which was high convenience. Fred Smith created a high-fidelity mail service.
Kevin ManeyIt felt like I'd been playing second-string football for a long time, when, suddenly, I was playing in the Super Bowl. Even when 'Basic Instinct' was a hit, I still felt like I was running with that ball toward the end zone. It took awhile for me to realize that I was already in the end zone with the ball down and the crowd screaming on its feet.
Sharon StoneIf you're making things at home, there is no structure - no end, no beginning. So releasing stuff is a really nice way to have dividers in between what you do, and giving yourself a kick up the ass and saying, "OK, that's the end of that period."
Aphex TwinI once succumbed to the fad of fasting and went for six days and nights without eating. It wasn't difficult. I was less hungry at the end of the sixth day than I was at the end of the second. Yet I know, as you know, people who would think they had committed a crime if they let their families or employees go for six days without food; but they will let them go for six days, and six weeks, and sometimes sixty years without giving them the hearty appreciation that they crave almost as much as they crave food.
Dale CarnegieThe greed of the billionaire class has got to end and we are going to end it for them.
Bernie SandersIrony won't save you from anything; humour doesn't do anything at all. You can look at life ironically for years, maybe decades; there are people who seem to go through most of their lives seeing the funny side, but in the end, life always breaks your heart. Doesn't matter how brave you are, or how reserved, or how much you've developed a sense of humour, you still end up with your heart broken. That's when you stop laughing.
Michel HouellebecqNo mistake about it. Ice is cold; roses are red; I'm in love. And this love is about to carry me off somewhere. The current's too overpowering; I don't have any choice. It may very well be a special place, some place I've never seen before. Danger may be lurking there, something that may end up wounding me deeply, fatally. I might end up losing everything. But there's no turning back. I can only go with the flow. Even if it means I'll be burned up, gone forever.
Haruki MurakamiYou get addicted to emotions. Our endorphins kick in and it's like a high. On the low end you might love roller coasters. On the high end you might be a bank robber or something.
Bryan CranstonMy happiness is not the means to any end. It is the end. It is its own goal. It is its own purpose.
Ayn RandHave endless patterns and repetitions accompanying your thoughtlessness, as if to say let go of that other more linear story, with its beginning, middle, and end, with its transcendent end, let go, we are the poem, we have come miles of life, we have survived this far to tell you, go on, go on.
Lidia YuknavitchPart of abandoning the all-or-nothing mentality is allowing yourself room for setbacks. We are bound to have lapses on the road to health and wellness, but it is critical that we learn how to handle small failures positively so that we can minimize their long-term destructive effects. One setback is one setbackโit is not the end of the world, nor is it the end of your journey toward a better you.
Jillian MichaelsI was put into office by the people who believed in my idea that corruption is the root of poverty; that an end to corruption would mean an end to poverty.
Benigno Aquino IIIAnd that's how things are. A day is like a whole life. You start out doing one thing, but end up doing something else, plan to run an errand, but never get there. . . . And at the end of your life, your whole existence has the same haphazard quality, too. Your whole life has the same shape as a single day.
Michael CrichtonBy millions of years, time winged onward through eternity, to the end - the end, of which, in the old-earth days, I had thought remotely, and in hazily speculative fashion. And now, it was approaching in a manner of which none had ever dreamed.
William Hope HodgsonFundamentals might be good for the first third or first 50 or 60 percent of a move, but the last third of a great bull market is typically a blow-off, whereas the mania runs wild and prices go parabolic... There is no training, classroom or otherwise, that can prepare for trading the last third of a move, whether it's the end of a bull market or the end of a bear market.
Paul Tudor JonesThe end of the story of Batman is he's dead. Because, in the end, the Batman dies. What else am I going to do? Retire and play golf? It doesn't work that way. It can't. I fight until I drop. And one day, I will drop.
Neil GaimanDespite everything - despite all this hatred, despite all this misunderstanding between nations and civilizations - I think love is the end. Love is the end.
Osama AlomarPeople who inspire others are those who see invisible bridges at the end of dead-end streets
Charles R. SwindollJust know that if you want to be a boxer you're going to get your face beaten constantly but then you may end up being a Mayweather or an Ali at the end of the day.
Kanye WestWhen coming up with Wonder Woman cover designs, sometimes people will pitch ideas to me, either the writer or the editor. And it's interesting, because I know they're not trying to, but they end up pitching things that end up feeling like damsel-in-distress covers, where the tension comes from her needing to be rescued somehow. And it's something I immediately push back against.
Cliff ChiangAt the end of the day, I can end up just totally wacky, because I've made mountains out of molehills. With meditation, I can keep them as molehills.
Ringo StarrThe fact that your voice, amplified to the degree where it reaches from one end of the country to the other, does not confer upon you greater wisdom than when your voice reached only from one end of the bar to the other.
Edward R. MurrowI know that happy things and fun things eventually come to an end. But things that are scary and sad come to an end too...they always do. Even if you can't always believe that , please don't give up. Live.
Natsuki TakayaGod Bless America started to become an almost ritualistic incantation at the end of political speeches really with Ronald Reagan. It appears occasionally before, but it was not that common. And of course since it was a song that wasn't written by Irving Berlin until the 20th century (laughter), none of the 19th century presidents said God Bless America at the end of speeches, either. I think that the symbolism which suggests that everybody is religious and that even presidents who believe in church and state feel obliged to do this.
Susan JacobyThen down came the lid--the day was lost, for art, at Sarajevo. World-politics stepped in, and a war was started which has not ended yet: a "war to end war." But it merely ended art. It did not end war.
Wyndham LewisArt grabs people by their eyeballs, it seduces them ... art is a means to an end rather than simply an end in itself.
Eric DrookerResearch indicates that once an uncommitted couple gets involved in sexual intercourse, the relationship usually begins to end. They have reached the superficial end of the physical aspects of the relationship, and they have no particularly compelling reason to explore its depths.
Chip IngramIf the intuition-mongering were abandoned, would that be the end of philosophy? It would be the end of a certain style of philosophy - a style that has cut philosophy off, not only from the humanities but from every other branch of inquiry and culture.
Philip KitcherWe all end up living secret lives. We create what we are willing to admire and admiring what we shouldn't confess to the secret ofour own sin, our own insufficiency, our own sadness. We all end up taking our secrets into the world and handing them over to strangers, only to realize it's often too late to claim them back. The very nature of time passing is sad beyond words. Memories mean they're gone.
Alexander Theroux