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If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (-), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.
Charles Scott SherringtonThe truth is that man is one individual with two aspects, just like one line with two ends. If you look at the ends, it is two. If you look at the line, it is one. One end of the line is limited, the other end of the line is unlimited. One end is man, the other end is God.
Hazrat Inayat KhanThe Roman Empire came to an end, but the Roman people didn't come to an end, so I see the American Empire coming to an end just as other empires have come to an end.
Howard ZinnA story is an end in itself. It is not written to teach, sell, explain or destroy anything. It is not written even to entertain. It is written as a man is born - an organic whole, dictated only by its own laws and its own necessity - an end in itself, not a means to an end.
Ayn RandSometimes I'll have an end in mind, but it's always false, always corny, just a dumb idea anyone could have, sitting on a barstool. An abstract thesis with no real life inside it. And then I start writing and the writing itself confounds me, taking away the comfort of knowing the end in advance. How is that even possible? Doesn't the conclusion come at the end? How can you begin with one - that seems odd, right?
Charles D'AmbrosioAt the end of the day, I don't think I am going to be judged by what happened in the 90's and 2000's, at the end of the day my career will be judged from beginning to end and everything in between.
Carlos MenciaIf I were to try to read, much less answer, all the attacks made on me, this shop might as well be closed for any other business. I do the very best I know how - the very best I can; and I mean to keep doing so until the end. If the end brings me out all right, what's said against me won't amount to anything. If the end brings me out wrong, ten angels swearing I was right would make no difference.
Abraham LincolnI am also very proud to be a liberal. Why is that so terrible these days? The liberals were liberatorsthey fought slavery, fought for women to have the right to vote, fought against Hitler, Stalin, fought to end segregation, fought to end apartheid. Liberals put an end to child labor and they gave us the five day work week! What's to be ashamed of?
Barbra StreisandJesus was the temple to end all temples, the priest to end all priests, & the sacrifice to end all sacrifices.
Timothy KellerWe are so anxious to achieve some particular end that we never pay attention to the psycho-physical means whereby that end is to be gained. So far as we are concerned, any old means is good enough. But the nature of the universe is such that ends can never justify the means. On the contrary, the means always determine the end.
Aldous HuxleyBut all good things come to an end, often a sad angry miserable end. The cause for such an end can usually be whittled down to one of three things: money, sickness, love lost.
James FreyThe end of lower art is to please, the end of average art is to raise the top, the end of superior art is to free.
Fernando PessoaYou think the end justifies the means, however vile. I tell you: the end is the means by which you achieve it. Today's step is tomorrow's life. Great ends cannot be attained by base means. You've proved that in all your social upheavals. The meanness and inhumanity of the means make you mean and inhuman and make the end unattainable.
Wilhelm ReichIt's like in the great stories, Mr. Frodo. The ones that really mattered. Full of darkness and danger, they were. And sometimes you didn't want to know the end. Because how could the end be happy? How could the world go back to the way it was when so much bad had happened? But in the end, it's only a passing thing, this shadow. Even darkness must pass.
J. R. R. TolkienGod knows; I won't be an Oxford don anyhow. I'll be a poet, a writer, a dramatist. Somehow or other I'll be famous, and if not famous, I'll be notorious. Or perhaps I'll lead the life of pleasure for a time and thenโwho knows?โrest and do nothing. What does Plato say is the highest end that man can attain here below? To sit down and contemplate the good. Perhaps that will be the end of me too.
Oscar WildeStories took twists and turns down fairy-tale paths or down very human everyday ones. You think youโre at the end of the book, and itโs only the end of a chapter.
Deb CalettiAnthropologists visit the temple sites and read the inscriptions and make up stories about the Maya, but they do not read the signs correctly. Its just their imagination. Other people write about prophecy in the name of the Maya. They say that the world will end in December 2012. The Mayan elders are angry with this. The world will not end. It will be transformed.
Carlos BarriosIrony won't save you from anything; humour doesn't do anything at all. You can look at life ironically for years, maybe decades; there are people who seem to go through most of their lives seeing the funny side, but in the end, life always breaks your heart. Doesn't matter how brave you are, or how reserved, or how much you've developed a sense of humour, you still end up with your heart broken. That's when you stop laughing.
Michel HouellebecqIf you can delude yourself by believing that there is some kind of Santa Claus out there who is going to bail you out in the end, then it will help you get through. Even if you are proven wrong in the end, you would have had a better life than a non-believer.
Woody AllenTo the former child migrants, who came to Australia from a home far away, led to believe this land would be a new beginning, when only to find it was not a beginning, but an end, an end of innocence - we apologise and we are sorry. To the mothers who lost the maternal right to love and care for their child - we apologise, and we are sorry.
Malcolm TurnbullThe loneliest you will get is in the most public of arenas: You will go to a place and end up in the smallest compartment possible, because it's a distraction to everybody, and you end up not getting to enjoy it like everyone else.
George ClooneyBut she knew this,โthat it was necessary for her happiness that she should devote herself to some one. All the elegancies and outward charms of life were delightful, if only they could be used as the means to some end. As an end themselves they were nothing.
Anthony TrollopeEverything on earth is a game. A passing thing. We all end up dead. We all end up the same, don't we?
PeleSo end-to-end encryption, keeps things encrypted and that means that law enforcement, without a warrant, cannot read that information.
Rod BeckstromPeople who inspire others are those who see invisible bridges at the end of dead-end streets
Charles R. SwindollThe chief end of our life is to live in communion with God. To this end the Son of God became incarnate, in order to return us to this divine communion, which was lost by the fall into sin. Through Jesus Christ, the Son of God, we enter into communion with the Father and thus attain our purpose.
Theophan the RecluseI'm amazed, that how salam (peace) is always the first word to start a meeting. but in prayer it is the end word. Maybe it means the end of prayer is the start of a meeting.
Ali ShariatiThere is no contradiction between technology and spirit. There is no contradiction between the search for intellectual integration and understanding and the psychedelic experience. There is no contradiction between ultra-advanced hyperspacial cyber culture and Paleolithic archaic culture. We have come to the end of our sojourn in matter. We have come to the end of our separateness.
Terence McKennaMan is born a predestined idealist, for he is born to act. To act is to affirm the worth of an end, and to persist in affirming the worth of an end is to make an ideal.
Oliver Wendell Holmes Sr.As playwrights, as poets, we have to look to ourselves, listen to our guts for the final answers about what changes to make. Everyone has advice about how to end your play differently. And it's not about right or wrong. At the end of the day, it's your baby and you know what's best.
Stephen KaramSo all I'm saying is, everything that seems important--our quarrels, or philosophical differences--in the end, it doesn't matter much. You know? In the end, what matters is what remains.
Thrity UmrigarI know that happy things and fun things eventually come to an end. But things that are scary and sad come to an end too...they always do. Even if you can't always believe that , please don't give up. Live.
Natsuki TakayaLove is the opposite of [lust]: respecting the other as an end unto himself or herself. When you love someone as an end unto himself, then there is no feeling of hurt; you become enriched through it. Love makes everybody rich.
RajneeshFaith shall save your Soul from Death. Without Faith, Death is a drowning, the end of ends, and what sane man wouldn't fear that? But with Faith, Death is nothing worse than the end of the voyage we call life, and the beginning of an eternal voyage in a company of our Loved Ones, with griefs and woes smoothed out, and under the capacity of our Creator.
David MitchellWhen you're a teenager, everything seems like the end of the world, and I don't think that's necessarily a silly thing. You're waking up and becoming aware that the world has problems and those problems affect you, whereas when you're young they don't seem to affect you that much even if you're aware of them. This dystopian trend picks up on that little part of your life where everything feels really extreme and it honors that part of your life and says, "Yeah. It is the end of the world. Look at it."
Veronica RothA hole had just appeared in the Galaxy. It was exactly a nothingth of a second long, a nothingth of an inch wide, and quite a lot of million light years from end to end. As it closed up [...] Two hundred and thirty-nine thousand lightly fried eggs fell out of it...materializing in a large woobly heap on the famine-struck land of Poghril in the Pansel system. The whole Poghril tribe had died out from famine except for one last man who died of cholesterol poisoning some weeks later.
Douglas AdamsArt grabs people by their eyeballs, it seduces them ... art is a means to an end rather than simply an end in itself.
Eric DrookerIf all the students who slept through lectures were laid end to end, they'd all be a lot more comfortable. If all the world's a stage, I want to operate the trap door.
Paul BeattyIt is good to have an end to journey towards; but it is the journey that matters, in the end.
Ursula K. Le GuinBegin with the end in mind. Start with the end outcome and work backwards to make your dream possible.
Wayne DyerWe are born into this time and must bravely follow the path to the destined end. There is no other way. Our duty is to hold on to the lost position, without hope, without rescue, like that Roman soldier whose bones were found in front of a door in Pompeii, who, during the eruption of Vesuvius, died at his post because they forgot to relieve him. That is greatness. That is what it means to be a thoroughbred. The honorable end is the one thing that can not be taken from a man.
Oswald SpenglerThe Taboo crowd was certainly less precious. They were happy to end up in a pile of vomit and booze at the end of the night. It was antifashion, in a sense. They were just as obsessive as the New -Romantics but they acted like they didn't care.
Boy GeorgeBefore 'Wings' came out, I told a few people that at the end of book one, readers should think Laurel made the right choice. Then, at the end of 'Spells,' they should understand why Laurel made the choice she did.
Aprilynne PikeI think in the end, I want to make sure that my kids come out of this thing on the other end in one piece. But I also know that that's how the rest of the country feels as well, so for that I am grateful.
Michelle ObamaAnyone who has ever studied the history of American diplomacy, especially military diplomacy, knows that you might start in a war with certain things on your mind as a purpose of what you are doing, but in the end, you found yourself fighting for entirely different things that you had never thought of before. In other words, war has a momentum of its own and it carries you away from all thoughtful intentions when you get into it. Today, if we went into Iraq, like the president would like us to do, you know where you begin. You never know where you are going to end.
George F. Kennan